Statins may cut Parkinson's risk
March 13, 2012
Statin users may get an added benefit from the cardioprotective lipid-lowering -- a modestly reduced risk of developing Parkinson's disease, researchers found.
Men and women in two large prospective cohorts were 26% less likely to develop Parkinson's disease if they were taking a statin than if they weren't currently on one (adjusted pooled P=0.049), Xiang Gao, MD, PhD, of Harvard and Brigham and Women's Hospital in Boston, and colleagues reported in the March issue of the Archives of Neurology.
The benefit appeared limited to statin users under age 60 at baseline, who saw a bigger impact of the drug with an adjusted pooled relative risk of 0.31 (P=0.02 for effect, P=0.03 for interaction with age).
Preclinical studies have pointed to several mechanisms of statins, such as a reducing oxidative stress, that would be expected to alleviate neuroinflammation and thus Parkinson's disease risk, Gao's group explained.
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