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Bruce A. Sullenger, PhD
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Bruce A. Sullenger, PhD

Director, Duke Translational Research Institute

Joseph and Dorothy Beard Professor

Department of Surgery




Durham , NC 27710
Work: (919) 684-6375

Biography:

Dr. Sullenger's laboratory focuses on the development of RNA-based therapeutic agents for the potential treatment of a range of diseases. To this end, he takes advantage of the fact that RNA is not just a passive carrier of genetic instructions inside of cells during the conversion of information from DNA to RNA to protein. Rather, RNA is an extremely versatile biological macromolecule. Certian RNAs can bind to specific proteins with high affinities, while others can for catalytic centers and perform enzymatic reactions. These facets of RNA coupled with the ease with which RNA can be manipulated in vitro make it a very powerful and unique therapeutic agent whose potential is largely untapped. During our endeavors, we plan to work closely with the members of the Molecular Therapeutics program as well as other faculty at the Duke University Medical Center to expedite the development and testing of these therapeutics.