The director of the DTMI is Robert Califf, MD, Vice Chancellor for Clinical and Translational Research, Duke University Medical Center.

• Transform how discoveries are translated into improved medical care
• Provide leadership and resources for clinical and translational research
• Evaluate novel methods and approaches
• Develop a community model to translate the findings of research from bench to bedside to population
• Monitor the impact of discoveries on communities using advanced informatics and care delivery methods

Purposes of the Clinical and Translational Programs

• Transformative, novel, and integrative academic home for Clinical and Translational Science
• Captivate, advance, and nurture a cadre of well-trained multi-disciplinary investigators and research teams
• Create an incubator for innovative research tools and information technologies
• Catalyze the application of new knowledge and techniques to clinical practice at the front lines of patient care

Key Functions of an Institutional Clinical and Translation Institute

• Development of novel clinical and translational methodologies
• Pilot and collaborative translational and clinical studies
• Biomedical Informatics
• Design, Biostatistics, and Clinical Research Ethics
• Regulatory Knowledge and Support
• Participant and Clinical Interactions Resource
• Community Engagement
• Translational Technologies and Resources
• Research Education, Training and Career Development

Grant Documents

The following documents (pdf files) are available for download:

• Duke CTSA Final Research Plan: Institutional Clinical and Translational Science Award

• Section G-1: Overview
• Section G-2-1: Novel Translational Methodologies
• Section G-2-2: Pilot Collaborative Studies
• Section G-2-3: Biomedical Informatics
• Section G-2-4: Biostatistics and Clinical Research Ethics
• Section G-2-5: Regulatory Knowledge and Support
• Section G-2-6: Clinical Research Unit
• Section G-2-7: Community Engagement
• Section G-2-8: Translational Technologies and Resources
• Section G-2-9: Research Education, Training and Career Development
• Section G-2-10: Other Programs
• Section G-3: Tracking and Evaluation
• Section G-4: Implementation Plan
• Section G-5: Tables

The National Institutes of Health’s Clinical and Translational Science Award (CTSA) consortium has expanded again with the recent addition of 14 more academic health centers in 11 states. The 2008 CTSA grants expand state representation in the consortium to Alabama, Colorado, Indiana, Massachusetts, and Utah. These 14 academic health centers join 24 others [including Duke] announced in 2006 and 2007 for a total of 38 institutions receiving CTSA funding to date.

Total funding for these new awards is $533 million over five years. When the CTSA program is fully implemented in 2012, the consortium will include approximately 60 CTSAs.

NIH and CTSA Institutions: working together as a national CTSA consortium

A major goal of the CTSA initiative is to develop a national consortium of CTSA institutions that will work together to transform the discipline of clinical and translational research across the country. The graphic below illustrates how NIH/NCRR will oversee Consortium-wide activities that are generated through trans-NIH CTSA subcommittees and their respective topic specific CTSA Committees.

For more information, contact:
Anthony R. Hayward, MD, PhD
Director, Division for Clinical Research Resources
National Center for Research Resources
National Institutes of Health
One Democracy Plaza, Room 906
6701 Democracy Boulevard, MSC 4874
Bethesda, Maryland 20892-4874 (20817 for express mail)
phone 301.435.0791
fax 301.480.3661
e-mail HaywardA@mail.nih.gov