Cecil Charles, PhD
DTRI Imaging Core
Associate Professor of Radiology
Director, Duke Image Analysis Laboratory (DIAL)

Dr. Charles is a chemist and an expert in MR imaging and spectroscopy with over 20 years of experience in nuclear magnetic resonance. He serves as the co-director of the Duke Center for Advanced Magnetic Resonance Development.

Dr. Charles has extensive experience in conducting brain imaging and spectroscopy studies serving as the Director of the Neuroimaging Core for the UNC Mental Health Clinical Research Center for the study of Neuroscience of Mental and Behavioral Disorders. He has had extensive experience in conducting longitudinal clinical trials with MRI and MRS used as biomarkers. He is part of the first NIH-sponsored clinical trial of MR in-vivo spectroscopy.

Mark Dewhirst, DVM, PhD
Director, DTRI Imaging Core
Gustavo S. Montana Professor of Radiation Oncology in the School of Medicine
Professor of Pathology

Dr. Dewhirst graduated from the University of Arizona in 1971 with a degree in Chemistry and Colorado State University in 1975 and 1979 with DVM and PhD degrees, respectively.

In addition to his pathology appointment, he holds appointments in the Department of Biomedical Engineering at Duke and in the Department of Anatomy Pathology and Radiology at the School of Veterinary Medicine at North Carolina State University. Dewhirst joined the faculty of Duke University in 1984 and was promoted to full professor in 1993. He received an endowed professorship in 2002.

Dewhirst directs a clinical program grant to study the use of hyperthermia in the treatment of cancer, and has research interests in tumor hypoxia, angiogenesis and drug transport, with an emphasis on translational research.

Pamela S. Douglas, MD, MACC, FASE
DTRI Imaging Core
Ursula Geller Professor of Research in Cardiovascular Diseases in the School of Medicine
Imaging Core, Duke Clinical Research Institute

Dr. Douglas is the Ursula Geller Professorship for Research in Cardiovascular Diseases at Duke University, having previously served on the faculties of the University of Pennsylvania, Harvard University, and the University of Wisconsin.

Douglas has served as CV Chief at two premier universities (Duke, Wisconsin) and as a past president of the American College of Cardiology and of the American Society of Echocardiography. Dr. Douglas also serves as the director of the Duke CV Imaging Core Lab and the COResearch Imaging Program.

Douglas is internationally known for her scientific work in noninvasive imaging, exercise physiology, and heart disease in women. Her contributions in imaging span an enormous range, from technological innovation to health care delivery, including shaping a national program for quality improvement in imaging. Dr Douglas also has a significant role in creating the field of heart disease in women as an early and persuasive champion of its distinctive importance and relevance. The DCRI Imaging Program spans the full spectrum of imaging research from technology development to quality and outcomes, and includes a fully compliant imaging core laboratory with expertise in all cardiovascular imaging modalities.

Daniel C. Sullivan, MD
DTRI Imaging Core
Professor of Radiology
Director, Imaging Program, Duke Comprehensive Cancer Center

Dr. Sullivan is a professor of radiology at Duke University Medical Center, and director of the Imaging Program in the Duke Comprehensive Cancer Center. He is also a science adviser to the Radiological Society of North America (RSNA).

Dr. Sullivan completed radiology residency and nuclear medicine fellowship in 1977 at Yale-New Haven Hospital, and was an academic radiologist for 20 years before joining NIH in 1997. He has held faculty appointments at Yale University Medical Center, Duke University Medical Center, and University of Pennsylvania Medical Center. His areas of clinical and research expertise are in nuclear medicine and breast imaging.

At NIH he was Associate Director of the Division of Cancer Treatment and Diagnosis of the National Cancer Institute (NCI), and Head of the Cancer Imaging Program (CIP) at NCI. While at NCI, Sullivan oversaw the Program’s four branches — diagnostic imaging, molecular imaging, image-guided therapy and imaging technology development. He also administered the Program’s portfolio of grants and contracts, which grew from approximately $49 million in FY1997 to $180 million in FY2007. CIP initiated several collaborative groups including the In Vivo Cellular and Molecular Imaging Centers, the Small Animal Imaging Resource Programs, the Lung Imaging Database Consortium, the Network for Translational Research in Optical Imaging, the American College of Radiology Imaging Network, and the Imaging Workspace within NCI’s caBIG program.

Brian Reynolds, Ph.D.
Project Leader Imaging Core - DTRI
ph:(919) 668-8370
e-mail: brian.reynolds@duke.edu

Brian’s primary responsibility is to serve as the Project Leader for the Imaging Core. In that role, Brian works with Mark Dewhirst, Cecil Charles, Pam Douglas, and DTMI faculty to advance the goals of the Core by realizing opportunities to foster translational research at Duke and in areas within Duke’s reach.

Dr. Reynolds comes to the DTRI with a broad base of clinical, medical research, medical communication and teaching experience in the academic, biotechnology and pharmaceutical sectors. His research interests span immunology, microbiology, oncology, and immunotoxicology with a focus on Alzheimer’s disease in recent years.

Most recently Brian served as Project Leader in the Global Clinical Operations Group at GSK on their Phase III Alzheimer’s program. There, he created medical education programs for physician’s and recruitment and educational programs for patients and caregivers and served on a multi-disciplinary team including Regional Medical Science, Clinical Monitoring, Medical Information, and Clinical Operations.

Immediately prior, Brian was the Director of Medical and Scientific Information at Voyager Pharmaceutical, a company engaged in recruiting a Phase III Alzheimer’s trial. At Voyager, Brian was responsible for outgoing scientific information, creating and delivering scientific presentations at national and international congresses in addition to managing Key Opinion Leader (KOL) and advocacy group relationships, and recruiting Medical and Scientific Advisory Board members. In addition, Brian had the opportunity to contribute to business development and due diligence interactions with biotechnology and pharmaceutical companies interested in potential partnerships.

Brian has also worked in the human resources area for a several years, specifically supporting pharmaceutical, biotechnology and clinical research organizations (including the DCRI). He once held a Senior Professional in Human Resources (SPHR) certification and has a Certificate in Human Resources Management from Duke. While serving as the National Manager for Clinical and Biotechnology Business Development for Kelly Scientific Resources, Brian co-authored what is now the world’s largest scientific internship program, the Future Scientists of America, and helped to create a large clinical staffing and outsourcing operation.

Early in his career, Brian worked as an assistant professor of Biology and Biochemistry at Alma College, a small liberal arts school in Michigan. During this time he was also an immunotoxicology and flow cytometry consultant to Dow Chemical.

Brian received a BA in Biology from Franklin College of Indiana in 1986. He went on to obtain a Ph.D. in Microbiology and Immunology from the Indiana University School of Medicine in 1996 where he studied rheumatoid arthritis and completed a post-doctoral fellowship at the Well’s Center for Pediatric Hematology and Oncology at Indiana. His post-doctoral research investigated approaches to creating tumor vaccines by inserting foreign genes into tumors with molecularly modified retroviruses. His lab was the first to demonstrate the cure of established, lethal cancer by vaccination in a mouse model.