Biomedical Informatics (R. Pietrobon)

The Biomedical Informatics Core will empower investigators to be leaders in the impending global effort to redefine human disease by using combined clinical and molecular profiling and to measure changes in health status across multiple dimensions as a routine function of biomedical informatics.

Biorepository & -Omics

These teams are leading the effort to develop a national resource for the spectrum of technologies that includes genomics, genetic polymorphism analysis, gene expression analysis, proteomics, and metabolomics. Other labs focus on understanding metabolic regulatory mechanisms and applying this knowledge to gain insight into chronic conditions and diseases such as obesity and diabetes.

Biostatistics (S. George)

As the practice of medicine becomes increasingly evidence-based and the wealth of information within medical and genomic databases grows dramatically, the core disciplines of biostatistics and computational biology are becoming increasingly important in medical research, training, and in the translation of research findings into practice.

Cell & Tissue Therapies (J. Kurtzberg)

This team is working on bone marrow transplant efforts in addition to making huge discoveries about DiGeorge syndrome.

Chemistry and Molecular Therapeutics (E. Toone)

The Small Molecule Synthesis facility at Duke University is a component of the Duke University Center for Chemical Biology and was established to provide synthetic organic chemistry capabilities to the entire University community.

Clinical and Translational Research Ethics, Law & Policy (L. Beskow)

The Clinical and Translational Research Ethics, Law and Policy (CTRELP) core has one primary aim: To identify ethical, legal, and policy issues encountered in carrying out clinical translational science and in applying that science in practice, and to identify options to address those issues.

Imaging (M. Dewhirst)

With the work of Drs. Dewhirst, Charles and Douglas, Duke is quite advanced in the use of new imaging technologies to help us view what is happening within the body.

Immune Monitoring and Vaccines (K. Weinhold)

The Immune Monitoring Laboratory is a GCLP-compliant laboratory that provides support for basic, translational, and clinical investigations. The lab focuses on assessing subtle effects on the human immune system (immunogenicity, immunocompetence, immune reconstitution, immunotoxicity, and immunopathology) of particular importance in trials of vaccines, cellular therapy, drug therapy, cancer immunotherapy, and auto-immune disorders.

Training and Education (E. Oddone) (see Clinical Research Training Program - CRTP)

Today, we recognize the need to create a smoother continuum of clinical and translational research education that spans pre-doctoral years to the crucial early faculty years and incorporates training that facilitates translation of basic and clinical sciences discoveries to the bedside and to the clinic. Moreover, the training must emphasize multi- and inter-disciplinary approaches to increasingly complex problems.

Pediatrics and Pediatrics Management (J. Li)

The mission of the Pediatrics core resource is to be a pioneering pediatric academic enterprise that enhances the health of children by fostering therapeutic discovery through collaborative clinical and translational research.

Nursing

Duke SON will rely heavily on DTMI infrastructure to support protocol development through pilot studies and to partner with other disciplines in effective community-based interventions. The DTMI will allow nurses to participate in large multidisciplinary efforts to train clinical investigators in translation science and to use nursing informatics and technology to rapidly collect data (e.g., nurse-sensitive indicators) from large-scale data sets and clinical repositories to develop and test approaches to gaining entrée to "pockets of risk" in clinical populations.

Regulatory Affairs (B. Burnett)

Regulatory Affairs will provide leadership and facile infrastructure support for investigators specially designed to accelerate the pace of translational research projects while protecting the quality and integrity of the research process and the safety of human subjects.